ACCURACY OF TIMING IN TSH SAMPLE COLLECTION FOR CONGENITAL HYPOTHYROIDISM SCREENING AT PRIMA MEDIKA GENERAL HOSPITAL DENPASAR

Gusti Ayu Kristalia Mustika Dewi; Didik Prasetya; Diah Prihatiningsih

doi:10.62567/micjo.v2i3.979

Authors

Gusti Ayu Kristalia Mustika Dewi STIKES Wira Medika Bali
Didik Prasetya STIKES Wira Medika Bali
Diah Prihatiningsih STIKES Wira Medika Bali

DOI:

https://doi.org/10.62567/micjo.v2i3.979

Keywords:

Neonates, Screening, ThTyroid Stimulating Hormone

Abstract

Congenital hypothyroidism (CH) is an endocrine disorder that can cause developmental delays if not detected and treated early. Congenital Hypothyroidism Screening (CHS) aims to detect abnormal levels of Thyroid Stimulating Hormone (TSH) in newborns before clinical symptoms appear. The timing of blood sample collection is a critical factor because TSH levels physiologically surge within the first 24 hours of life. This study aims to determine the accuracy of TSH sampling time in CH screening at Prima Medika General Hospital, Denpasar. A descriptive analytical method was used with a total sampling technique involving 105 neonates who underwent CHS from October to December 2024. Secondary data were obtained from laboratory request forms and the Laboratory Information System (LIS). Results showed that 92.4% of samples were collected on the second day of life, which aligns with the ideal window of 48–72 hours, and only 1.9% of neonates had elevated TSH levels. The study concludes that most sample collections met the recommended timing, contributing to valid results and effective CHS implementation. Timely sampling plays a vital role in early CH detection and reflects the overall quality of neonatal laboratory services.

Downloads

Download data is not yet available.

References

Anggraini, R., Patria, S. Y., & Julia, M. (2017). Ketepatan Waktu Pelayanan Skrining Hipotiroidism Kongenital di Yogyakarta. Sari Pediatri, 18(6), 436. https://doi.org/10.14238/sp18.6.2017.436-42

Cherella, C. E., & Wassner, A. J. (2017). Congenital hypothyroidism: insights into pathogenesis and treatment. International Journal of Pediatric Endocrinology, 2017(1), 11. https://doi.org/10.1186/s13633-017-0051-0

Darmawan, S. F., Hartati, D., Sulistyorini, C., & Risnawati, R. (2024). The Influence of Health Education on the Interest of TM III Pregnant Women in Screening for Congenital Hypothyroidism in Newborn Babies. Journal of Midwifery and Nursing, 6(2), 464–469. https://doi.org/10.35335/jmn.v6i2.5069

Decroli, E., & Kam, A. (2017). Dampak Klinis Thyroid-Stimulating Hormone. Jurnal Kesehatan Andalas, 6(1), 222. https://doi.org/10.25077/jka.v6i1.674

Dumilah, R., Yulifah, R., Mansur, H., Suprapti, S., & Darwanty, J. (2023). Implementasi Pelaksanaan Program Skrining Hipotiroid Kongenital (Shk): Literature Review. Media Penelitian Dan Pengembangan Kesehatan, 33(4), 168–178. https://doi.org/10.34011/jmp2k.v33i4.1810

Hiola, F. A. A., Hilamuhu, F., & Katili, D. N. O. (2022). Faktor-Faktor yang Mempengaruhi Cakupan Pelaksanaan Skrining Hipotiroid Kongenital di Rsu Prof. Dr. H. Aloe Saboe Kota Gorontalo. Media Publikasi Promosi Kesehatan Indonesia (MPPKI), 5(4), 435–440. https://doi.org/10.56338/mppki.v5i4.2218

Kemenkes RI. (2014). Peraturan Menteri Kesehatan RI Nomor 78 Tentang Hipotiroid Kongenital. In Lampiran Peraturan Menteri Kesehatan RI Nomor 78 Tentang Hipotiroid Kongenital Pedoman Hipotiroid Kongenital (Issue 1751).

Khairunnisa, M., Purwoko, S., Latifah, L., & Yunitawati, D. (2022). Evaluasi Pelaksanaan Program Stimulasi, Deteksi, dan Intervensi Dini Tumbuh Kembang di Magelang. Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini, 6(5), 5052–5065. https://doi.org/10.31004/obsesi.v6i5.1885

Lima-Oliveira, G., Volanski, W., Lippi, G., Picheth, G., & Guidi, G. C. (2017). Pre-analytical phase management: a review of the procedures from patient preparation to laboratory analysis. Scandinavian Journal of Clinical and Laboratory Investigation, 77(3), 153–163. https://doi.org/10.1080/00365513.2017.1295317

Majid, H., Ahmed, S., Siddiqui, I., Humayun, K., Karimi, H., & Khan, A. H. (2020). Newborn screening for congenital hypothyroidism: improvement in short-term follow-up by audit and monitoring. BMC Research Notes, 13(1), 563. https://doi.org/10.1186/s13104-020-05400-y

Martini, N. W. D., Nyandra, M., & Kurniati, N. M. (2022). Studi Kasus Hipotiroid pada Anak di UPTD Puskesmas Kediri I Kabupaten Tabanan. Jurnal Kesehatan, Sains, Dan Teknologi (Jakasakti), 1(1). https://doi.org/10.36002/js.v1i1.1948

Muharis, I. A., & Triani, E. (2024). Literature Review: Skrining Dan Tatalaksana Hipotiroid Kongenital. Jurnal Ilmu Kedokteran Dan Kesehatan, 11(1), 057–064. https://doi.org/10.33024/jikk.v11i1.13000

Nugraha, I. B. A., & Pradiptha, I. P. Y. (2023). Hipotiroid Kongenital Dan Gangguan Pendengaran. Ganesha Medicine, 3(2), 77–83. https://doi.org/10.23887/gm.v3i2.66825

Pulungan, A. B., Puteri, H. A., Faizi, M., Hofman, P. L., Utari, A., & Chanoine, J.-P. (2024). Experiences and Challenges with Congenital Hypothyroidism Newborn Screening in Indonesia: A National Cross-Sectional Survey. International Journal of Neonatal Screening, 10(1), 8. https://doi.org/10.3390/ijns10010008

Setyaningsih, E., Avisha, F., & Syahnidep, R. (2023). Hipotiroid Kongenital. Artikel Kesehatan Rumah Sakit Universitas Indonesia. https://rs.ui.ac.id/umum/berita-artikel/kelainan-penyakit/hipotiroid-kongenital?utm_source=chatgpt.com

Setyaningsih, W., & Wulandari, R. D. (2022). The Evaluation of Congenital Hypothyroidsm Screening Program in Indonesia: A Literature Review. Jurnal Aisyah : Jurnal Ilmu Kesehatan, 7(2). https://doi.org/10.30604/jika.v7i2.1161

Sonia, Zulliati, Redjeki, D. S. S., & Suhartati, S. (2025). Identifikasi Pelaksanaan Skrining Hipotiroid Kongenital di Wilayah Kerja UPT Puskesmas Bengkuang. Health Research Journal of Indonesia, 3(3), 187–192. https://doi.org/10.63004/hrji.v3i3.633